Celiac Disease

Typical Features of Celiac Disease

Anatomical System Features
General Short stature
Weight loss
Swelling caused by fluid in the body's tissues (oedema)
Thickening of the flesh under the toenails and fingernails (clubbing)
Flattened nails with concavities (koilonychia)
Gastrointestinal Anorexia, nausea, vomiting
Abdominal distension (bloating) and pain
Diarrhoea and constipation
Bacterial overgrowth
Lactose intolerance
Psychiatric Depression
Neurological Numbness of the extremities, tingling (peripheral neuropathy)
Difficulty in coordinating movements (ataxia)
Epilepsy (recurrent unprovoked seizures)
Tingling, numbness and pricking feeling similar to ‘pins and needles’ or a limb being ‘asleep’ (paraesthesia)
Haematological Anaemia
Folic acid and iron deficiency
Raised mean corpuscular volume
Haemorrhagic manifestations
Biochemical Reduced serum calcium
Raised alkaline phosphatase
Raised hepatic amino-transferase (liver dysfunction)
Reproduction Infertility
Recurrent miscarriages
Musculoskeletal Soft bones due to vitamin D deficiency (osteomalacia)
Brittle bones (osteoporosis)
Bone pain
Disease of the muscle (myopathy)
Involuntary contraction of muscles due to vitamin D deficiency (tetany)
Renal Frequent passage of urine at night (nocturnal diuresis)
Skin Red blistering rashes (dermatitis herpertiformis)
Manifestations of malabsorption Vitamin and mineral deficiencies including folic acid, iron, calcium and vitamin D.
Protein and calorie malnutrition